Blar i forfatter "Dragomir, Mihnea Paul"

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    • Classical and noncanonical functions of miRNAs in cancers 

      Dragomir, Mihnea Paul; Knutsen, Erik; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-30)
      Alterations in microRNAs (miRNAs) expression are causative in the initiation and progression of human cancers. The molecular events responsible for the widespread differential expression of miRNAs in malignancy are exemplified by their location in cancer-associated genomic regions, epigenetic mechanisms, transcriptional dysregulation, chemical modifications and editing, and alterations in miRNA ...

    • CRISPR/Cas9 to Silence Long Non-Coding RNAs 

      Rosenlund, Ingrid A; Calin, George A.; Dragomir, Mihnea Paul; Knutsen, Erik (Chapter; Bokkapittel, 2021-06-24)
      Knock-out (KO) of long non-coding RNAs (lncRNAs) enables functional characterization of this still poorly described group of transcripts. One of the most efficient and simplest methods to achieve complete KO of a lncRNA is by employing CRISPR/Cas gene editing. As most lncRNAs are not well annotated, their individual functional regions are not defined, and the majority of the transcripts are not ...

    • FuncPEP: A Database of Functional Peptides Encoded by Non-Coding RNAs 

      Dragomir, Mihnea Paul; Manyam, Ganiraju C; Ott, Leonie Florence; Berland, Léa; Knutsen, Erik; Ivan, Cristina; Lipovich, Leonard; Broom, Bradley M.; Calin, George A (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-23)
      Non-coding RNAs (ncRNAs) are essential players in many cellular processes, from normal development to oncogenic transformation. Initially, ncRNAs were defined as transcripts that lacked an open reading frame (ORF). However, multiple lines of evidence suggest that certain ncRNAs encode small peptides of less than 100 amino acids. The sequences encoding these peptides are known as small open reading ...

    • A Holistic Perspective: Exosomes Shuttle between Nerves and Immune Cells in the Tumor Microenvironment 

      Dragomir, Mihnea Paul; Moisoiu, Vlad; Manaila, Roxana; Pardini, Barbara; Knutsen, Erik; Anfossi, Simone; Amit, Moran; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-31)
      One of the limitations of cancer research has been the restricted focus on tumor cells and the omission of other non-malignant cells that are constitutive elements of this systemic disease. Current research is focused on the bidirectional communication between tumor cells and other components of the tumor microenvironment (TME), such as immune and endothelial cells, and nerves. A major success of ...

    • The long noncoding RNA CCAT2 induces chromosomal instability through BOP1-AURKB signaling 

      Chen, Baoqing; Dragomir, Mihnea Paul; Fabris, Linda; Bayraktar, Recep; Knutsen, Erik; Liu, Xu; Tang, Changyan; Li, Yongfeng; Shimura, Tadanobu; Ivkovic, Tina Catela; Cruz De los Santos, Mireia; Anfossi, Simone; Shimizu, Masayoshi; Shah, Maitri Y.; Ling, Hui; Shen, Peng; Multani, Asha S.; Pardini, Barbara; Burks, Jared K.; Katayama, Hiroyuki; Reineke, Lucas C.; Huo, Longfei; Syed, Muddassir; Song, Shumei; Ferracin, Manuela; Oki, Eiji; Fromm, Bastian; Ivan, Cristina; Bhuvaneshwar, Krithika; Gusev, Yuriy; Mimori, Koshi; Menter, David; Sen, Subrata; Matsuyama, Takatoshi; Uetake, Hiroyuki; Vasilescu, Catalin; Kopetz, Scott; Parker-Thornburg, Jan; Taguchi, Ayumu; Hanash, Samir M.; Girnita, Leonard; Slaby, Ondrej; Goel, Ajay; Varani, Gabriele; Gagea, Mihai; Li, Chunlai; Ajani, Jaffer A.; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-15)
      Background & Aims - Chromosomal instability (CIN) is a carcinogenesis event that promotes metastasis and resistance to therapy by unclear mechanisms. Expression of the colon cancer–associated transcript 2 gene (CCAT2), which encodes a long noncoding RNA (lncRNA), associates with CIN, but little is known about how CCAT2 lncRNA regulates this cancer enabling characteristic.<p> <p>Methods - We ...